近日，付丽娜团队在学术研究上取得重大成果，两篇论文分别发表于国际顶级期刊Advanced Composites and Hybrid Materials与Carbohydrate Polymers，分别为《Glutamic acid loaded separable microneedle composite for long acting hair regeneration treatment》和《 A novel multifunctional self-assembled nanocellulose based scaffold for the healing of diabetic wounds》。
Recently, Dr. Fu Lina’s team has achieved significant academic results, with two papers published respectively in the top international journals Advanced Composites and Hybrid Materials and Carbohydrate Polymers. The papers are titled Glutamic acid-loaded separable microneedle composite for long-acting hair regeneration treatment and A novel multifunctional self-assembled nanocellulose-based scaffold for the healing of diabetic wounds.
两篇论文聚焦生物医用材料与纳米技术，创新成果显著。首先，第一篇论文创新性开发了一种基于PLGA的可分离式谷氨酸微针贴片，通过机械刺激与4周缓释双重机制，实现雄激素性脱发治疗效率较米诺地尔提升46.75%，且仅需每周1次给药。该研究首次揭示谷氨酸通过调控Wnt/β-catenin通路激活毛囊干细胞，促进血管新生和组织再生。其次，第二篇论文创新地设计了一种新型纳米纤维素基智能支架，用于治疗糖尿病伤口。该支架由丝素蛋白和氧化铈纳米颗粒负载，具有优异的孔隙率、吸水性、透气性、保水性、可控降解性和抗氧化性。体外实验表明，该支架能够促进支架的降解并表现出对革兰氏阳性菌和革兰氏阴性菌的抗菌活性。体内实验表明，该支架能够减少糖尿病小鼠伤口部位的炎症并促进胶原蛋白沉积、血管生成和再上皮化，表现出良好的生物相容性和生物降解性。其疗效优于目前市售的膜敷料（3M敷料）和医用PELNAC敷料（三类医疗器械）。
The two papers focus on biomedical materials and nanotechnology, with remarkable innovative achievements. Firstly, the first paper innovatively develops a PLGA-based separable glutamic acid microneedle patch. Through the dual mechanisms of mechanical stimulation and 4-week sustained release, it achieves a 46.75% improvement in the treatment efficiency of androgenetic alopecia compared with minoxidil, with only once-weekly administration required. This study reveals for the first time that glutamic acid activates hair follicle stem cells by regulating the Wnt/β-catenin pathway, promoting angiogenesis and tissue regeneration.
Secondly, the second paper innovatively designs a novel nanocellulose-based intelligent scaffold for the treatment of diabetic wounds. The scaffold is loaded with silk fibroin and cerium oxide nanoparticles, and possesses excellent porosity, water absorption, air permeability, water retention, controllable degradability and antioxidant properties. In vitro experiments show that the scaffold can promote its own degradation and exhibit antibacterial activity against both Gram-positive and Gram-negative bacteria. In vivo experiments demonstrate that the scaffold can reduce inflammation at the wound site of diabetic mice, and promote collagen deposition, angiogenesis and re-epithelialization, showing good biocompatibility and biodegradability. Its therapeutic effect is superior to currently commercially available membrane dressings (3M dressings) and medical PELNAC dressings (Class III medical devices).
具体内容上，第一篇论文研究开发了一种基于PLGA和透明质酸的可分离生物降解微针贴片，负载GA用于治疗AGA。微针通过机械刺激和持续4周释放GA，促进毛囊细胞增殖及血管生成，在AGA小鼠模型中毛发再生效率（83.68%）显著优于米诺地尔组（56.93%），且给药频率更低，为临床提供了一种安全有效的非侵入式治疗新策略。 其次，第二篇论文论文本文提出了一种基于纳米纤维素的新型多功能智能支架，用于治疗糖尿病伤口。该支架具有优异的孔隙率、吸水性、透气性、保水性、可控降解性和抗氧化性。实验验证了该支架具有抗菌、抗炎、促血管生成和组织再生等作用。该支架有望成为一种有效的糖尿病伤口治疗材料，并具有广阔的临床应用前景。
In terms of specific content, the first paper researches and develops a separable biodegradable microneedle patch based on PLGA and hyaluronic acid, loaded with GA for the treatment of AGA. Through mechanical stimulation and sustained release of GA for 4 weeks, the microneedles promote hair follicle cell proliferation and angiogenesis. In the AGA mouse model, the hair regeneration efficiency (83.68%) is significantly superior to that of the minoxidil group (56.93%), with a lower administration frequency, providing a safe and effective non-invasive new therapeutic strategy for clinical practice.
Secondly, the second paper proposes a novel multifunctional intelligent scaffold based on nanocellulose for the treatment of diabetic wounds. The scaffold possesses excellent porosity, water absorption, air permeability, water retention, controllable degradability and antioxidant properties. Experiments have verified that the scaffold has antibacterial, anti-inflammatory, pro-angiogenic and tissue regeneration-promoting effects. This scaffold is expected to become an effective material for the treatment of diabetic wounds and has broad clinical application prospects.
其中，Advanced Composites and Hybrid Materials近年影响因子为23.2，属于中科院SCI材料化学一区TOP期刊，在中科院/JCR分区分区中位居Q1区，是材料科学领域顶级期刊，2024年影响因子达23.2+，稳居JCR Q1及中科院1区，近年影响因子持续跃升并多次登顶领域榜首1257 ，主要涵盖材料设计、表面和界面科学/工程、制造、结构控制、性能设计、器件制造和其他应用的顶级研究以及相关的仿真/建模研究” ；Carbohydrate Polymers的影响因子为10.7，为中科院化学领域的 1区 Top 期刊，并在应用化学和有机化学等小类中均为 1 区，JCR 分区中， POLYMER SCIENCE 领域为 Q1 区，同时在 CHEMISTRY, APPLIED 和 CHEMISTRY, ORGANIC 领域也均为 Q1 区。Carbohydrate Polymers作为中科院化学领域1区、JCR Q1的顶级期刊，凭借其高影响因子（10.7）和权威的学术地位，是化学和材料科学领域的重要学术资源。Carbohydrate Polymers聚焦糖科学与多糖，涵盖生物能源、材料、药物输送、食品、健康、纳米技术等，多学科交叉，推动碳水化合物聚合物基础与应用研究。
Among them, Advanced Composites and Hybrid Materials has a recent impact factor of 23.2. It is a TOP journal in the CAS SCI Material Chemistry Category 1, ranked Q1 in both CAS/JCR classifications, and stands as a top-tier journal in the field of materials science. Its 2024 impact factor reached over 23.2, firmly maintaining its position in JCR Q1 and CAS Category 1. The journal’s impact factor has been rising steadily in recent years and has repeatedly topped the rankings in its field ¹²⁵⁷. It mainly covers cutting-edge research on material design, surface and interface science/engineering, manufacturing, structure control, performance design, device fabrication, and other applications, as well as related simulation/modeling research.
Carbohydrate Polymers has an impact factor of 10.7, classified as a TOP journal in CAS Chemistry Category 1, and also ranks Q1 in subcategories such as Applied Chemistry and Organic Chemistry. In JCR classifications, it is Q1 in the POLYMER SCIENCE field, and also Q1 in both CHEMISTRY, APPLIED and CHEMISTRY, ORGANIC fields. As a top journal in CAS Chemistry Category 1 and JCR Q1, Carbohydrate Polymers is an important academic resource in chemistry and materials science due to its high impact factor (10.7) and authoritative academic status. The journal focuses on glycochemistry and polysaccharides, covering bioenergy, materials, drug delivery, food, health, nanotechnology, etc., featuring interdisciplinary research and promoting fundamental and applied studies on carbohydrate polymers.
此次成果不仅彰显了付丽娜团队扎实的学术功底与创新能力，更为相关领域研究提供了新思路与新方向，显著提升了黄淮学院在材料科学领域的学术声誉。她用实际行动展示了学院在前沿科研方面的实力，还激励了师生投身科研工作，为学生树立了榜样，激发了他们的科研热情。同时，这些论文也增强了学院在研究生招生中的吸引力，有助于吸引更多优秀学生。此外，研究成果的应用前景有望促进校企合作，推动科研成果转化，为学院带来更多科研项目和资金支持，助力学院在学科建设和科研发展上迈上新台阶。
These achievements not only demonstrate the solid academic foundation and innovative capabilities of Fu Lina’s team, but also provide new ideas and directions for research in related fields, significantly enhancing Huanghuai University’s academic reputation in the field of materials science. With practical actions, she has showcased the university’s strength in cutting-edge scientific research, inspired teachers and students to engage in research work, set an example for students, and stimulated their enthusiasm for scientific research. Meanwhile, these papers have also increased the university’s attractiveness in postgraduate enrollment, helping to attract more outstanding students. In addition, the application prospects of the research results are expected to promote university-enterprise cooperation, drive the transformation of scientific research achievements, bring more research projects and financial support to the university, and assist the university in taking a new step in discipline construction and scientific research development.